A. OVCAR-4 and OVCAR-3 cells were treated with 10 μg/ml of either IgG or MMP-14 Ab, Avastin (VEGF Ab), TIMP-1 Ab, MMP-7 Ab or MMP-8 Ab and migrated towards stromal matrix (fibroblast conditioned media) for 5 hours. B. OVCAR-4 and OVCAR-3 cells were treated with MMP-14 or luciferase RNAi, serum starved and migrated towards malignant ovarian ascites for 5 hours. C. Transwells were coated with 20 μg of matrigel. OVCAR-4 and OVCAR-3 cells were treated with either IgG, MMP-14, Avastin (VEGF Ab), MMP-7 or TIMP-1 antibody and migrated towards stromal matrix for 20 hours. D. Transwells were coated with Type 1 rat tail collagen, and cells were migrated towards stromal matrix for 40 hours. Columns mean, bars SE; * P<0.05, * * P<0.005.