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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Cancer Res. 2013 Feb 19;73(8):2457–2467. doi: 10.1158/0008-5472.CAN-12-1426

Figure 2. Blockade of MMP-14 inhibits migration and invasion of ovarian cancer cells.

Figure 2

A. OVCAR-4 and OVCAR-3 cells were treated with 10 μg/ml of either IgG or MMP-14 Ab, Avastin (VEGF Ab), TIMP-1 Ab, MMP-7 Ab or MMP-8 Ab and migrated towards stromal matrix (fibroblast conditioned media) for 5 hours. B. OVCAR-4 and OVCAR-3 cells were treated with MMP-14 or luciferase RNAi, serum starved and migrated towards malignant ovarian ascites for 5 hours. C. Transwells were coated with 20 μg of matrigel. OVCAR-4 and OVCAR-3 cells were treated with either IgG, MMP-14, Avastin (VEGF Ab), MMP-7 or TIMP-1 antibody and migrated towards stromal matrix for 20 hours. D. Transwells were coated with Type 1 rat tail collagen, and cells were migrated towards stromal matrix for 40 hours. Columns mean, bars SE; * P<0.05, * * P<0.005.