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. 2014 Apr;21(4):205–214. doi: 10.1101/lm.032094.113

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© 2014 Simpson et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — COMT-OE mice require more training on the 5-CSRTT and show signs of impulsive and compulsive behavior. (A) COMT-OE mice required significantly more training sessions to reach criterion compared to control mice. (B) Once COMT-OE mice had acquired the 1-sec stimulus duration version of the 5-CSRTT, they were equally accurate at the shorter stimulus durations. (C) During testing on the shorter stimulus durations, COMT-OE mice made more premature responses. (D) During testing on the shorter stimulus durations, COMT-OE mice made more perseverative responses. Control n = 6, COMT-OE n = 6. (*) P < 0.05.