Systolic blood pressure (A), plasma cholesterol concentration (B), and the adhesion of leukocytes (C) and platelets (D) in cerebral venules, measured in the following groups of mice: intact ApoE-KO (n=6), uninephrectomized ApoE-KO (Uni ApoE-KO, n=6), Uni ApoE-KO fed (daily) a cholesterol-enriched diet (Uni ApoE-KO + HCD, n=8), Uni ApoE-KO with DOCA-salt treatment fed normal diet (Uni ApoE-KO + DOCA-salt, n=8) or (daily) cholesterol-enriched diet (Uni ApoE-KO + DOCA-salt + HCD, n=7). * P<0.05 vs. intact ApoE-KO; # P<0.05 vs. Uni ApoE-KO; @ P<0.05 vs. Uni ApoE-KO + HCD; & P<0.05 vs. ApoE-KO + DOCA-salt.