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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Apr 10;78(1):81–93. doi: 10.1016/j.neuron.2013.02.011

Figure 3. Acute ketamine administration in mice recapitulates the psychosis-associated pattern of hippocampal hypermetabolism.

Figure 3

Changes in hippocampal relative CBV (rCBV; see Methods for calculation) in anesthetized mice following acute administration of ketamine (30mg/kg) are shown. Compared to saline (black lines), ketamine (red lines) evoked significant increases in CA1 (Panel A) and subiculum rCBV (Panel B), significant at 16min post injection. The EC (Panel C), CA3 (Panel D), and DG (Panel E) showed non-significant increases relative to saline. *p < 0.05 peak difference in rCBV, relative to saline. Data are represented as mean ± SEM.