Skip to main content
. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Neuron. 2013 Apr 10;78(1):81–93. doi: 10.1016/j.neuron.2013.02.011

Figure 7. The effects of extracellular glutamate on PV+ interneuron density in the repeated ketamine exposure model.

Figure 7

(A) Intermittent repeated ketamine exposure resulted in a decrease in the apparent density of PV+ interneurons in hippocampal CA subfields; this effect is attenuated by LY379268 co-treatment. ** p < 0.01 Saline/Ketamine group versus saline control. Data are represented as mean ± SEM.

(B) Decreases in PV+ expression (relative the mean of the saline control group) are associated at trend level with increases in basal rCBV measured after one month of repeated treatment with saline only (open symbols), ketamine with saline co-treatment (red symbols) or ketamine with LY379268 co-treatment (blue symbols) (r=.49, p=.06).

(C) Across the same treatment groups there is a negative association between post-treatment basal rCBV measured after drug wash-out and the change in hippocampal volumes across the 1-month treatment period (r=.57, p=.006).