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. Author manuscript; available in PMC: 2014 Mar 26.
Published in final edited form as: Compr Physiol. 2013 Apr;3(2):667–692. doi: 10.1002/cphy.c110014

Figure 16.

Figure 16

Telemetry electrocardiogram (ECG) recordings in Clcn2−/− mice and their Clcn2+/+ and Clcn2+/− littermates during treadmill exercises. (A) Representative ECG (Lead II) recordings in Clcn2+/+, Clcn2+/−, and Clcn2−/− mice while they were subjected to treadmill exercise at (a) rest period: acclimation at 0 m/min, incline 0° for 5 min; (b) walk period: walking at 5m/min, incline 0° for 5 min; (c) run period: running at 15 m/min, uphill incline 8° for 5 min. (B) Mean heart rate during the last minute of each treadmill exercise segment for the Clcn2+/+ (n = 6), Clcn2+/− (n = 5), and Clcn2−/− (n = 7) mice. (C) Mean heart rate of the Clcn2+/+ (n = 5) and Clcn2−/− (n = 4) mice before (Control, Cont) and after the intraperitoneal injection of atropine (Atro), propranolol (Prop), or atropine plus propranolol (Atro + Prop) during the last minute of each treadmill exercise segment (rest, walk, and run). *, P < 0.05; **, P < 0.01; ***, P < 0.001 versus Clcn2+/+; #, P < 0.05; ##, P < 0.01; ###, P < 0.001 versus Clcn2+/−; $, P < 0.05; $$, P < 0.01; $$$, P < 0.001 versus control (Cont); d, P < 0.05 versus rest (89).