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. Author manuscript; available in PMC: 2014 Mar 26.
Published in final edited form as: Compr Physiol. 2013 Apr;3(2):667–692. doi: 10.1002/cphy.c110014

Figure 6.

Figure 6

Comparison of pressure overload-induced remodeling of wild-type and Clcn3−/− mouse hearts. Hearts from age-matched wild-type (WT, Clcn3+/+) and Clcn3−/− mice were excised 1 week (top panel) or 10 weeks (bottom panel) after minimally invasive transverse aorta binding (MTAB) or sham operation are shown. Hearts were cleaned of blood and connective tissues and then fixed in 4% paraformaldehyde. Bar = 5 mm. Compared to WT mice disruption of ClC-3 gene significantly changed the remodeling process after MTAB. Both left ventricle and atrium were extremely enlarged after 10 weeks of MTAB. [Adapted, with permission, from Duan (48)]. (Copyright Request: Duan D. J Physiol 587: 2163–2177, 2009)