Fig. 3.

The response to statins is abolished in LIRKO livers. LIRKO and control mice were fed a standard chow diet with or without supplementation of 0.1% lovastatin for 1 week and euthanized in the nonfasted state. A: Hepatic cholesterol was measured using a colorimetric assay. B–H: Gene expression was measured using real-time PCR. I: LDLR protein was measured in liver homogenates by immunoblotting. J, K: After 5 days on the chow diet with or without lovastatin supplementation, mice were fasted for 4 h, and plasma obtained for the measurement of triglycerides and cholesterol. (n = 4–8; *P < 0.05 versus control mice under the same treatment conditions; ^#P < 0.05 versus untreated mice of the same genotype.)