Figure 3.
Antibody (IgM and IgG1) formation in response to vaccination (intraperitoneal injection on days 0 and 57) with Prevnar1320 (2.2 μg of each polysaccharide) or with PBS57+PBS150 as a simple mixture (4 μg of PBS150 and 1 μg of PBS57) or in liposome formulation, as indicated. Each injection contained an equivalent amount of pneumococcal polysaccharide serotype 14. Sera were collected at indicated intervals to measure IgM and IgG1 antibody titers against S. pneumoniae serotype 14. Each dot represents the serum titer of an individual mouse at the indicated time. Statistical analysis: * p-value < 0.05; *** p-value < 0.001. The first time periods at which p-values below 0.05 or 0.001 are indicated.