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. 2014 Mar 18;171(7):1642–1654. doi: 10.1111/bph.12504

Figure 2.

Figure 2

Blood glucose lowering in male obese (fa/fa) Zucker rats after daily dosing of AZD1656 at 3 mg·kg−1·day−1 (n = 9) and 10 mg·kg−1·day−1 (n = 7) or vehicle (n = 9). (A) 12 h free-feeding blood glucose profiles at day 1. Sample sizes: 3 mg·kg−1·day−1, n = 9; 10 mg·kg−1·day−1, n = 6; vehicle, n = 9. (B) Glucose AUC(0–12 h) values (mM·h) at day 1. (C) 12 h free-feeding blood glucose profiles at day 28. Sample sizes: 3 mg·kg−1·day−1, n = 9; 10 mg·kg−1·day−1, n = 7; vehicle, n = 9. (D) Glucose AUC(0–12 h) values (mM·h) at day 28. Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus vehicle; †P < 0.05, †††P < 0.001 versus AZD1656 at 3 mg·kg−1·day−1.