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. 2014 Mar 18;171(7):1642–1654. doi: 10.1111/bph.12504

Figure 3.

Figure 3

Blood glucose and insulin levels following OGTT in male obese (fa/fa) Zucker rats after 14 days dosing of AZD1656 at 3 mg·kg−1·day−1 (n = 9) and 10 mg·kg−1·day−1 (n = 7) or vehicle (n = 9). (A) Glucose levels during OGTT. Sample sizes: 3 mg·kg−1·day−1, n = 9; 10 mg·kg−1·day−1, n = 7; vehicle, n = 9. (B) Glucose AUC(0–12 h) values (mM·h). Data are mean ± SEM. *P < 0.05, **P < 0.01 versus vehicle, †P < 0.01, versus AZD1656 at 3 mg·kg−1·day−1. (C) Insulin levels at t = 0 and t = 20 min during OGTT. Sample sizes: 3 mg·kg−1·day−1, n = 8; 10 mg·kg−1·day−1, n = 8; vehicle: n = 9 (t = 0 min); 3 mg·kg−1·day−1, n = 8; 10 mg·kg−1·day−1, n = 6; vehicle, n = 9 (t = 20 min). Data are mean ± SEM. **P < 0.01, ***P < 0.001 versus t = 0 min.