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Body weight gain over 49 weeks in male gkwt/del mice on HF diet ± GKA71 and male wild-type mice on HF or chow diets: gkwt/del mice on HF diet alone (n = 10), gkwt/del mice on HF + GKA71 at 2.5 mg·kg−1·day−1 (n = 7–10), gkwt/del mice on HF + GKA71 at 5 mg·kg−1·day−1 (n = 10), wild-type mice on HF alone (n = 8–10), wild-type mice on chow diet alone (n = 10). Data are mean ± SEM. *P < 0.05 versus gkwt/del mice on HF diet alone.
