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. 2014 Mar 18;171(7):1642–1654. doi: 10.1111/bph.12504

Figure 5.

Figure 5

Weekly blood glucose values (1 h before start of dark phase) and compound exposures over 49 weeks in male gkwt/del mice on HF diet ± GKA71. (A) Blood glucose values for mice on HF diet alone (n = 10) or HF diet + GKA71 at 2.5 mg·kg−1·day−1 (n = 7–10), and compound exposure, expressed as a multiple of the mouse EC50. (B) Blood glucose values for mice on HF diet alone or HF diet + GKA71 at 5 mg·kg−1·day−1 (n = 10), and compound exposure. Blood glucose values are mean ± SEM. Compound exposure ratios are mean values over 24 h. Error bars indicate Cmax and Cmin. Week 0 values show mean baseline glucose in control and treatment groups at day −3 relative to diet switch. Three animals from the 2.5 mg·kg−1·day−1 GKA71 group were removed during the study as noted under Methods.