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Twenty-four hour free-feeding blood glucose profiles for male gkwt/del mice on HF diet ± GKA71. (A) Baseline, (B) 1 month, (C) 3 months, (D) 6 months, (E) 9 months, (F) 12 months. Mice on HF diet alone (n = 10), HF diet + GKA71 at 2.5 mg·kg−1·day−1 (n = 7–10), HF diet + GKA71 at 5 mg·kg−1·day−1 (n = 10). Data are mean ± SEM. (G) Glucose AUC(–1 to 23 h) values (mM·h) for all monthly free-feeding glucose profiles over 12 months. Data are mean ± SEM.
