Table 2.
Study 1: terminal metabolic parameters in plasma samples from obese (fa/fa) and lean (fa/+) male Zucker rats
| Genotype | Treatment | Total cholesterol (mM) (n) | Lactate (mM) (n) | Triglycerides (mM) (n) |
|---|---|---|---|---|
| fa/fa | Vehicle | 18.76 ± 5.37 (9) | 4.69 ± 0.19 (8) | 4.92 ± 1.98 (9) |
| fa/fa | AZD1656 (3 mg·kg−1·day−1) | 13.91 ± 3.16 (8) | 5.09 ± 0.50 (8) | 5.93 ± 2.07 (8) |
| fa/fa | AZD1656 (10 mg·kg−1·day−1) | 15.64 ± 4.46 (7) | 4.91 ± 0.60 (7) | 4.75 ± 1.72 (7) |
| fa/+ | Vehicle | 2.41 ± 0.11a (10) | 4.58 ± 0.43 (10) | 1.00 ± 0.10b (10) |
Values are mean ± SEM.
a
P < 0.01 versus fa/fa vehicle.
b
P < 0.05 versus fa/fa vehicle.