Table 3.
Study 2: mean blood glucose levels in male gkwt/del and wild-type mice over weeks 2–49
| Genotype | Diet | Mean blood glucose (mM) (n) | Mean total GKA71 over 24 h interval (μM) | Free drug/EC50 |
|---|---|---|---|---|
| gkwt/del | HF | 15.1 ± 0.2 (10) | – | – |
| gkwt/del | HF + GKA71 (2.5 mg·kg−1·day−1) | 12.7 ± 0.1a, b (7) | 21.64 ± 1.20 | 0.21 ± 0.01 |
| gkwt/del | HF + GKA71 (5 mg·kg−1·day−1) | 11.9 ± 0.7a (10) | 39.70 ± 2.35 | 0.11 ± 0.006 |
| gkwt/wt | HF | 8.4 ± 0.1 (8) | – | – |
| gkwt/wt | Chow | 8.8 ± 0.1 (10) | – | – |
Values are mean ± SEM.
a
P < 0.001 versus gkwt/del on HF diet.
b
P < 0.01 versus gkwt/del on HF diet + GKA71 (5 mg·kg−1·day−1).