Table 4.
Study 2: terminal metabolic parameters from male gkwt/del mice and gkwt/wt littermates
| Genotype | Diet | Plasma total cholesterol (mM) (n) | Plasma triglycerides (mM) (n) | Hepatic triglycerides (μmol·g−1) (n) | Hepatic glycogen (μmol·g−1) (n) | HbA1c (%) (n) |
|---|---|---|---|---|---|---|
| gkwt/del | HF | 6.40 ± 0.63 (7) | 1.02 ± 0.06 (7) | 0.19 ± 0.04 (8) | 26.34 ± 7.46 (9) | 7.97 ± 0.16 (9) |
| gkwt/del | HF + GKA71 (2.5 mg·kg−1·day−1) | 5.96 ± 0.40 (6) | 1.03 ± 0.08 (6) | 0.29 ± 0.06 (6) | 23.84 ± 3.35 (7) | 7.37 ± 0.22a (7) |
| gkwt/del | HF + GKA71 (5 mg·kg−1·day−1) | 5.29 ± 0.72 (8) | 1.00 ± 0.14 (8) | 0.25 ± 0.04 (10) | 25.95 ± 6.00 (10) | 7.09 ± 0.29a (7) |
| gkwt/wt | HF | 8.41 ± 0.41a (6) | 1.02 ± 0.12 (6) | 0.34 ± 0.06a (8) | 19.59 ± 5.27 (7) | 5.73 ± 0.09b (7) |
| gkwt/wt | Chow | 2.88 ± 0.10b (9) | 1.26 ± 0.07 (9) | 0.06 ± 0.01b (9) | 7.70 ± 3.62a (8) | 6.22 ± 0.07b (8) |
Values are mean ± SEM.
a
P < 0.05 versus gkwt/del on HF diet.
b
P < 0.001 versus gkwt/del on HF diet.