Table 2.
Comparison of body and bladder weight, bladder layer thickness, and the magnitude of the contractile response to a high concentration of potassium in SAMP8 and SAMR1 mice
| SAMR1 | SAMP8 | ||||
|---|---|---|---|---|---|
| ♂ | ♀ | ♂ | ♀ | ||
| Body weight (g) | 38.4 ± 1.02 (19) | 35.2 ± 0.93 (19) | 32.0 ± 0.71 (19)*** | 30.7 ± 1.42 (19)** | |
| Bladder weight (% body weight) | 1.52 ± 0.14 (19) | 0.71 ± 0.10 (19)††† | 1.92 ± 0.23 (19) | 0.73 ± 0.14 (19)††† | |
| Layer thickness (μm) | Lamina propria | 302 ± 30.2 (5) | 296 ± 22.3 (5) | 330 ± 40.1 (5) | 325 ± 75.0 (5) |
| Muscle layer | 431 ± 46.3 (5) | 406 ± 34.0 (5) | 413 ± 35.4 (5) | 375 ± 25.1 (5) | |
| Contractile force (mN) [K+ 120 mM] | 9.61 ± 0.82 (15) | 7.03 ± 0.82 (15)††† | 10.8 ± 1.21 (15) | 7.32 ± 0.73 (15)††† | |
The values represent the mean ± SE (n):
**
P < 0.01,
***
P < 0.001 versus SAM-R1;
†††
P < 0.001 versus ♂ (anova followed by Student's t-test).