Figure 5.
CSY0073 inhibits the production of TNF-α, CXCL1 and CXCL2 in airways induced by Pseudomonas aeruginosa LPS. (A) IL-6 (B) TNF-α, (C) CXCL1, (D) CXCL2, (E) IL-1β and (F) IL-12p40 in bronchoalveolar lavage fluid (BALF) 3 and 24 h after challenge with 100 μg·kg−1 LPS or PBS. Mice were pretreated for 2 h with vehicle (V: DMSO), CSY0073 (CSY) or AZM. Data are mean ± SEM for 7–8 mice per group. Statistical analysis was done for each time point, 3 h (*) or 24 h (#) with anova followed by Bonferroni's multiple comparison test. **P < 0.01, ***P < 0.001 and ****P < 0.0001.