Skip to main content
. 2014 Mar 26;9(3):e92806. doi: 10.1371/journal.pone.0092806

Table 1. Characteristics of liquid and lyophilized influenza vaccine formulations.

Liquid Lyophilized
Vaccine Size (nm) PDI Size (nm) PDI HA1 recovery (%) Antigenic recovery (%)
WIV 137±1 0.07 146±3 0.09 137±11 111±1
Virosome 131±2 0.13 151±9 0.24 110±9 118±4
Split 520±14 0.63 150±4 0.43 115±4 95±7
Subunit 103±2 0.41 131±4 0.32 115±11 100±2

Size and polydispersity index (PDI) are shown for liquid formulations and reconstituted lyophilized formulations. Recovery of HA1 and antigenicity of lyophilized vaccines are shown as a percentage of vaccines before freeze-drying. Data represent mean ± SD; n = 3.