Table 4. Adaptive mutations observed in the P2 and P3 regions of EV71:TLLm and EV71:TLLmv viral genomes.

	EV71:BS vs EV71:TLLm 14—				EV71:BS vs EV71:TLLmv11
		Amino acid changes				Amino acid changes
Genome region	Nucleotide changes	Polyprotein 15—	Mature protein 16—	Genome region	Nucleotide changes	Polyprotein	Mature protein
2A	G 3722 A	G 992 E	G 130 E	2A	G 3722 A	G 992 E	G 130 E
2C	A 4366 G	T 1207 A	T 96 A	2C	A 4366 G	T 1207 A	T 96 A
3A					C 5117 T	A 1457 V	A 17 V
3B	T 5357 C	L 1537 P	L 11 P	3B	T 5357 C	L 1537 P	L 11 P
3C	A 5557 G	I 1604 V	I 56 V	3C	A 5557 G	I 1604 V	I 56 V
	A 5569 G	I 1608 V	I 60 V		A 5569 G	I 1608 V	I 60 V
3D	A 6211 G	N 1822 D	N 91 D	3D	A 6070 T	T 1775 S	T 44 S 17—
	T 6835 A	S 2030 T	S 299 T4		T 6137 C	V 1797 A	V 66 A3
	A 7128 G	R 2127 S	R 396 S5		A 6211 G	N 1822 D	N 91 D
	T 7247 C	V 2167 A	V 436 A5		C 6404 G	S 1886 C	S 155 C
					T 6592 G	W 1949 G	W 218 G 18—
					T 6835 A	S 2030 T	S 299 T4
					A 7128 G	R 2127 S	R 396 S 19—
					T 7247 C	V 2167 A	V 436 A5

^{14 —}Mutations are based on alignment with the reference EV71:BS genome.

^{15 —}Numbering of amino acids in the uncleaved polyprotein prior to maturation.

^{16 —}Numbering of amino acids in the mature protein.

^{17 —}Mutation located in the Ring finger domain of the RNA-dependent RNA Polymerase.

^{18 —}Mutation located in the Palm domain of the RNA-dependent RNA Polymerase.

^{19 —}Mutation located in the Thumb domain of the RNA-dependent RNA Polymerase.