Figure 2. CFTR inhibition by MalH-2 affects blood platelet counts, plasma MIP-2 levels, and parameters of lung inflammation in E. coli pneumonia.

Wildtype mice were divided into two groups to receive an ip of either PBS or MalH2 (3 mg/kg), then intratracheally challenged with E. coli (10⁷ cfu). At 4 h, mice were killed to collect plasma and BAL and measure the relevant parameters. A. Blood platelet counts. B. Plasma MIP-2 levels. C. BAL neutrophils. D. BAL MIP-2 levels. Values are presented as mean ± SD. Sample size and P values are indicated in each panel.