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. 2014 Mar 26;9(3):e93003. doi: 10.1371/journal.pone.0093003

Figure 5. Effects of blockade of PSGL-1, P-selectin, PAF, or correction of mutated CFTR trafficking on plasma lipoxin A4 in LPS-induced lung inflammation.

Figure 5

The F508del mice were divided into four groups and received either vehicles or treatments before LPS challenge. The mice were killed at 24 h to collect plasma. A. Plasma lipoxin A4 levels under blockade of PSGL-1. B. Plasma lipoxin A4 levels under blockade of P-selectin. C. Plasma lipoxin A4 levels under antagonism of PAF. D. Plasma lipoxin A4 levels under correction of mutated CFTR trafficking. E. Effect of anti-P-selectin on BAL neutrophils. Two-way ANOVA was used for statistical analysis. *P<0.05, *P<0.01 for F508del mice receiving treatment versus F508del mice receiving vehicle. Four groups of mice showed in each figure were intratracheally challenged with LPS. Values are presented as mean ± SD.