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. 2014 Mar 26;9(3):e93103. doi: 10.1371/journal.pone.0093103

Figure 6. Anticancer effect of DOX, oHSV1 and oHSV2 in 4T1 breast tumors.

Figure 6

The mice bearing 4T1 tumors were treated with DOX, oHSV1 or oHSV2 as described in the Materials and Methods section. A) The tumor volume was measured every 4 days following treatments. The data are presented as the mean ± SEM (n = 12), p<0.001. B) The median survival times for the 3 groups are illustrated in Kaplan–Meier survival curves (n = 12). Median survival: Control, 28 days; DOX, 34 days, p = 0.0034; oHSV2, 34 days, p = 0.0009; and oHSV1, 31 days, p = 0.0043. C) The weight of the mice was measured every 4 days following treatments. The data are presented as the mean ± SEM (n = 12). ***, p<0.001 and ns, no significant differences. D) Schematic of the experimental design. Each spot represents one treatment.