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. 2014 Mar 26;9(3):e93103. doi: 10.1371/journal.pone.0093103

Figure 7. Anticancer effect of DOX coupled with oHSV2 in different treatment combinations in 4T1 breast tumors.

Figure 7

Mice bearing 4T1 tumors were treated as described in the Materials and Methods section. And the Control, oHSV2 and DOX groups were the same in Fig 6 and 7. A) The tumor volume of mice was measured every 4 days following treatments. The data are presented as the mean ± SEM (n = 12). B) The median survival times for the 3 groups are illustrated in Kaplan–Meier survival curves (n = 12). Median survival: DOX/oHSV2, 44 days, p<0.001; oHSV2/DOX, 35 days, p<0.001; and DOX+oHSV2, 15 days. C) The weight of mice was measured every 4 days following treatments. The data are presented as the mean ± SEM (n = 12), *, p<0.05; **, p<0.01; and ***, p<0.001. D) Schematic of the experimental design. Each spot represents one treatment.