Table 3.

Association between gender/menopause and fibrosis severity with and without adjusting for other variables.

	Model 1	P value	Model 2	P value	Model 3	P value
	COR [95% CI]		COR [95% CI]		COR 95% CI
Gender and menopause		0.03		0.04		0.10
Pre-menopausal women	-		-		-	-
Men	1.36 [0.91–2.03]		1.66 [1.09–2.54]		1.62 [1.04–2.53]
Post-menopausal women	1.70 [1.15–2.52]		1.56 [1.03–2.35]		1.35 [0.88–2.07]
Hepatocyte ballooning				<0.01		<0.01
Grade 0	-		-		-
Grade 1	-		1.65 [1.08–2.51]		1.48 [0.97–2.26]
Grade 2	-		4.73 [2.87–7.85]		4.15 [2.50–6.94]
Portal inflammation				<0.01		<0.01
Grade 0	-		-		-
Grade 1	-		2.68 [1.91–2.68]		2.85 [2.02–4.05]
Enrolling site Metabolic and Weight Loss Surgery		<0.01		<0.01		0.02
No	-		-		-
Yes	0.51 [0.37–0.71]		0.61 [0.42–0.89]		0.56 [0.35–0.91]
Race, Black						<0.01
No	-		-
Yes	-		-		0.38 [0.22–0.65]
BMI, kg/m2	-		-		1.01 [0.99–1.03]	0.33
Diabetes/Prediabetes						<0.01
No	-		-
Yes	-		-		2.17 [1.54–3.08]
Hypertension						0.30
No	-		-
Yes	-		-		1.23 [0.84–1.80]

Model 1: adjusted for the site of enrollment

Model 2: adjusted for the site, grade of portal inflammation, hepatocyte ballooning

Model 3: adjusted for the site, grade of portal inflammation, hepatocyte ballooning, black race, BMI, diabetes/prediabetes, and hypertension.

Age was not included in the multivariate model due to the strong correlation between menopause and age