Table 2.
Cardiac structure and function by echocardiographic imaging at ambulatory LVAD settings and reduced LVAD support.
| Parameter | Ambulatory Settings | Reduced Support | Change | P |
|---|---|---|---|---|
| RPM | 9200 (9200,9600) | 6600 (6200,7400) | −2600 (−2200,−2800) | <0.001 |
| Pulse Index | 5.1 (4.2,5.9) | 6.7 (6.3,6.9) | 1.6 (0.8,2.5) | <0.001 |
| Power, watts | 6.2 (5.5,7.1) | 2.9 (2.7,3.5) | −2.9 (−2.6,−4.2) | <0.001 |
| Heart rate, bpm | 78 (70,86) | 73 (67,84) | 0 (0,−5) | 0.25 |
| Doppler BP, mmHg | 84 (78,88) | 82 (80,90) | 2 (−4,8) | 0.44 |
| Inflow Velocity, m/s | 0.72 (0.62,0.89) | 0.55 (0.46,0.64) | −0.18 (−0.06,−0.29) | <0.001 |
| Outflow Velocity, m/s | 0.81 (0.69,0.94) | 0.80 (0.66,0.96) | −0.01 (0.05,−0.10) | 0.62 |
| LVEDD, cm | 5.2 (4.3,5.7) | 5.7 (4.6,6.5) | 0.3 (0.2,0.9) | <0.001 |
| LVESD, cm | 4.7 (4.1,5.3) | 5.3 (4.2,5.9) | 0.5 (0.3,0.9) | <0.001 |
| RVEDA, cm2 | 25.0 (21.6,32.4) | 20.2 (16.8,23.9) | −3.6 (−0.7,−7.6) | 0.002 |
| LV-GCS, % | −9.5 (−8.3 ,−13.9) | −10.5 (−8.3,−13.5) | −0.8 (1.6,−1.7) | 0.76 |
| LV-FAC, % | 26 (20,29) | 21 (17,31) | −1 (2,−3) | 0.34 |
| RV-FAC, % | 40 (38,43) | 37 (32,44) | −3 (1,−8) | 0.33 |
| E wave velocity, cm/s | 71 (56,75) | 75 (49,84) | 5 (−6,14) | 0.41 |
| Average E' velocity, cm/s | 9.0 (7.0,11.2) | 8.3 (6.5,9.8) | −0.6 (0.2,−3.2) | 0.07 |
| LV filling pressures (E/e') | 8.1 (6.1,8.6) | 8.5 (6.4,9.7) | 1.0 (0.0,2.5) | 0.044 |
| RV-RA gradient, mmHg | 17 (16,23) | 23 (17,29) | 5 (−1,9) | 0.018 |
| RV Cardiac Output, L/min | 5.2 (3.9,6.6) | 4.3 (3.9,4.9) | −0.5 (0.1,−1.7) | 0.15 |
| PVR, Wood units | 1.7 (1.4,2.1) | 2.7 (2.3,3.2) | 0.7 (0.4,1.4) | 0.001 |
Data presented as median (IQR). P value from signrank test for paired data. RPM = rotations per minute; bpm = beats per minute, BP = blood pressure; LVEDD = left ventricular end diastolic diameter, LVESD = left ventricular end systolic diameter; RVEDA = right ventricular end diastolic area; LV-GCS = left ventricular global circumferential strain; LV-FAC = left ventricular fractional area change; RV-FAC = right ventricular fractional area change; RV-RA = right ventricular-right atrial; RV = right ventricular; PVR = pulmonary vascular resistance.