Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Leukemia. 2013 Sep 26;28(4):917–927. doi: 10.1038/leu.2013.279

Figure 2. CS1-CAR NK cells eradicate CS1+ but not CS1− MM cells.

Figure 2

A) Determination of CS1 expression on the surface of L363, IM9, and U266 MM cell lines by flow cytometry after cells were stained with anti-CS1 mAb or isotype-matched control antibody. B–D) Cytotoxic activity of mock-transduced or CS1-CAR-transduced NK-92 or NKL cells against IM9 (B), L363 (C) and U266 (D) cells using a standard chromium-51 release assay. NK-92-EV and NKL-EV indicate empty vector (EV) control-transduced NK-92 and NKL cells, respectively. NK-92-CS1-CAR and NKL-CS1-CAR indicate transduction of NK-92 and NKL cells, respectively, with a CS1-CAR construct. * and ** indicate P < 0.05 and P < 0.01, respectively.