Fig. 3.

Feedback loops that regulate accumulation of the CPC on the inner centromere. The numbers in white circles in the summarizing image at the top indicate the different feedback loops. These loops are clarified in the lower part of the figure. Loop 1a covers the Aurora B-Haspin circuit and loop 1b the Aurora B-Repo-Man-PP1 loop. Loop 2a involves Aurora B-ATM-Bub1 and loop 2b Aurora B-Mps1-Bub1. Loop 3 involves INCENP/Aurora B-Plk1. See main text for details. Kinases are shown in red and phosphatases in purple