Table 1.

Chemotherapy regimen

Week of regimen	Euro EWING 99 Protocol
Week 12 (Figs 1b and 2, after cycle 4)	Cycles 1–4	Vincristine, ifosfamide, doxorubicin, etoposide (VIDE) × 4
Week 16 (Fig. 1c, after cycle 6)	Cycles 5–6	Vincristine, cyclophosphamide, doxorubicin, etoposide (VCDE) × 2. Ifosfamide replaced by cyclophosphamide due to potential tubulopathy
	Surgical resection performed after cycle 6
	Cycles 7–15: maintenance cycles. Radiotherapy performed after cycle 8	Vincristine, actinomycin, cyclophosphamide (VAC) × 8
	Cumulative doses	Vincristine, ifosfamide 36 g m−2, doxorubicin 360 mg m−2, etoposide 2340 mg m−2, cyclophosphamide 11·625 g m−2
Week 92 (Fig. 1d), 36 weeks after completion of chemotherapy