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Quadruplex and duplex DNA SPR equilibrium binding constants (KA × 106 M-1) for the strong binding site. na is not available. nd, cannot be determined accurately since KA < 1.0 × 103 M-1.
| SPR Ligand KA (× 106 M-1) for a single-site fit | |||||
|---|---|---|---|---|---|
| hTel | c-kit1 | c-kit2 | c-myc | Duplex | |
| BRACO-1991 | 31.0 | na | na | na | 0.5 |
| 9a | 1.4 | 2.1 | 5.1 | 14.0 | nd |
| 9b | 1.1 | 1.4 | 5.0 | 2.1 | nd |
| 9c | 0.4 | 0.4 | 3.1 | 0.9 | nd |
