Table 6.
Long-term (1 week) effects on MCF7 cell growth. vc represents experiments performed solely with a vehicle control.
| Concentration (μM) | PDa | % of Control (vc)b | % Senescencec | |
|---|---|---|---|---|
| vc | - | 4.11 ± 0.34 | 100.0 ± 8.3 | 0.7 ± 0.2 |
| 9a | 5.00 | 3.79 ± 0.12 | 92.2 ± 3.0 | 1.0 ± 0.3 |
| 10.00 | 3.00 ± 0.38 | 73.1 ± 9.2 | 1.7 ± 1.6 | |
| 9b | 1.00 | 4.53 ± 0.07 | 110.4 ± 1.8 | 1.1 ± 1.1 |
| 1.75 | 4.50 ± 0.03 | 109.6 ± 0.73 | 3.1 ± 0.2 | |
| 2.25 | 2.73 ± 0.20 | 66.5 ± 5.0 | 2.4 ± 0.7 | |
| 9c | 3.50 | 3.94 ± 0.24 | 96.0 ± 5.9 | 1.6 ± 0.9 |
| 7.00 | 3.35 ± 0.03 | 81.5 ± 0.8 | 3.1 ± 0.4 | |
| 9h | 2.00 | 3.66 ± 0.00 | 89.2 ± 0.0 | 1.29 ± 0.0 |
| 3.50 | 3.46 ± 0.34 | 84.3 ± 8.2 | 1.33 ± 0.8 | |
| 11e | 1.00 | 3.40 ± 0.26 | 82.9 ± 6.3 | 3.0 ± 0.4 |
| 2.00 | 1.81 ± 0.10 | 44.0 ± 2.4 | 4.1 ± 1.2 |
a
PD, population doublings ± sd for 1 week MCF7;
b
percentage of 1 week population doublings normalized to the control (vc = 100%) ± sd;
c
the percentage of senescent cells assessed by the β-galactosidase assay ± sd.101