Table 3.

Loci reaching the significance threshold in the analysis of LDL

Chromosome	Window start	Window end	SKAT P	Empirical P	Gene
1	55230403	55258652	7.44 × 10−6	0.013
1	55258652	55293452	9.37 × 10−6	0.015	PCSK9
19	50016356	50069307	1.51 × 10−6	0.002
19	50069307	50140305	4.52 × 10−7	0.001	APO cluster

Note: Window start and window end are the boundaries of sliding windows. SKAT P is the P-value reported by SKAT, showing the significance of random effects in the mixed model. Empirical P is obtained based on minimal P values from 1000 permutations, as detailed in the text, to adjust for multiple testing across the autosomes.