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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1188–1195. doi: 10.1016/j.ijrobp.2013.12.043

Figure 2. Radiotherapy prior to Ad5-GUCY2C amplifies GUCY2C-specific T cells and reduces tumor growth.

Figure 2

(A) Mice challenged with CT26-GUCY2C cells (day 0) were treated with Ad5-GUCY2C or 8 Gy on day 7 and then treated with the opposing modality on day 14, generating two cohorts: Ad5→RT (n=10) and RT→Ad5 (n=10). Tumor volumes and GUCY2C-specific T cell responses were quantified on day 28. (B) T cell responses to GUCY2C were increased in the RT→Ad5 cohort compared to Ad5→RT. There was no difference in Ad5-specific T cell responses. Tumor cure rates (C) were increased and volumes (D) were decreased following RT→Ad5 compared to Ad5→RT.