Table 2.
Effects of curcumin co-administration on cadmium-induced oxidative stress and changes in redox status.
| Parameters | Normal Control | Normal control + Curcumin (mg/kg) | Cd Control | Cd + Curcumin (mg/kg) | ||
|---|---|---|---|---|---|---|
| 50 | 100 | 50 | 100 | |||
| Aortic superoxide anion (Counts/mg dry wt./min) | 161.2 ± 15.1 | 160.4 ± 9.5 | 158.7 ± 8.6 | 1202.4 ± 121.9 * | 851.9 ± 73.6 *,# | 711.5 ± 23.0 *,#,† |
| Urinary nitrate/nitrite (nmol/mg creatinine) | 909.7 ± 74.8 | 895.5 ± 57.5 | 920.0 ± 41.7 | 2074.6 ± 102.4 * | 1499.9 ± 43.4 *,# | 1116.5 ± 156.7 #,† |
| Plasma malondialdehyde (μM) | 15.4 ± 0.6 | 15.0 ± 1.3 | 15.9 ± 0.4 | 32.3 ± 2.4 * | 25.6 ± 3.3 *,# | 17.8 ± 1.5 #,† |
| Plasma protein carbonyls (nmol/mg protein) | 1.4 ± 0.09 | 1.4 ± 0.06 | 1.4 ± 0.06 | 3.5 ± 0.4 * | 2.0 ± 0.2 *,# | 1.7 ± 0.4 # |
| Blood GSH (μM) | 825 ± 69 | 811 ± 46 | 801 ± 31 | 270 ± 21 * | 510 ± 40 *,# | 603 ± 32 *,#,† |
| Blood GSH/GSSG | 149 ± 13 | 143.5 ± 11 | 146 ± 11 | 27 ± 3 * | 58 ± 7 *,# | 109 ± 5 *,#,† |
Mice received CdCl2 (100 mg/L in drinking water) alone or combined with curcumin (50 or 100 mg/kg, p.o.). GSH, reduced glutathione; GSSG, oxidized glutathione. Data are expressed as mean ± S.E., n = 8–10/group. * p < 0.01 compared with normal control group, # p < 0.01 compared with Cd control group, † p < 0.05 compared with Cd + curcumin (50 mg/kg).