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Population pharmacokinetic model parameters of the final model.
| Parameter | Mean | %SE |
|---|---|---|
| Structural model parameters | ||
| Clearance (CL) (L/h/kg) | 89.1 | 8.2 |
| Volume of central compartment (Vc) (L/kg) | 21.8 | 14.5 |
| Inter compartment clearance (Q) (L/h/kg) | 26.5 | 19.6 |
| Volume of peripheral compartment (Vp) (L/kg) | 17.4 | 14.4 |
| Interindividual variability | ||
| %CV of CL (ωCL) | 6.06 | 1.23 |
| %CV of Vc (ωV) | 31.6 | FIX |
| Residual variability | ||
| Proportional residual error | −0.208 | 11.9 |
| OFV | 168.8 |
