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. Author manuscript; available in PMC: 2014 Mar 27.
Published in final edited form as: Nature. 2011 Dec 21;480(7378):480–489. doi: 10.1038/nature10673

Figure 3. T cell targets for immunoregulatory antibody therapy.

Figure 3

In addition to specific antigen recognition through the TCR, T cell activation is regulated through a balance of positive and negative signals provided by costimulatory receptors. These surface proteins are typically members of either the TNF receptor or B7 superfamilies. Agonistic antibodies directed against activating costimulatory molecules and blocking antibodies against negative costimulatory molecules may enhance T cell stimulation to promote tumor destruction.