Figure 1.

Search outline for candidate genes identifed by RNA-Seq. Genes differentially expressed in KCOT, primary SC and healthy GG were first identified by RNA-Seq. The RNA-Seq results were compared to microarray data, which was performed to identify differentially expressed genes in KCOT primary stromal fibroblasts and in DC primary SC (data not shown). The genes were then subjected to further selection based on their function, to identify candidate genes that may affect the progression of KCOT. DC, dentigerous cysts; GG, gingival primary stromal fibroblast cells; KCOT, keratocystic odontogenic tumors; RNA-Seq, RNA sequencing; SC, stromal fibroblast cell.