Table 3. Candidate genes possibly involved in keratocystic odontogenic tumor progression.
| Name | RNA-Seq | Microarray | Regulation | Function |
|---|---|---|---|---|
| LARP6 | 2.004 039 | 1.735 885 1 | Up | Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2 |
| LOXL4 | 1.856 549 | 3.174 347 4 | Up | Modulate the formation of a collagenous extracellular matrix |
| TCTA | 1.817 763 9 | 1.503 996 7 | Up | Required for cellular fusion during osteoclastogenesis |
| KIT | 4.258 54 | 4.790 408 | Down | This is the receptor for stem cell factor (mast cell growth factor) |
| TNFRSF25 | 3.598 541 | 1.561 969 | Down | The protein encoded by this gene is a member of the TNF-receptor superfamily |
| RGS12 | 1.796 471 | 1.527 165 | Down | This protein may play a role in tumorigenesis |
| RICTOR | 1.721 887 | 1.859 07 | Down | Subunit of mTORC2, which regulates cell growth and and survival in response to hormonal signals |
ECM, extracellular matrix; LARP6, La ribonucleoprotein domain family, member 6; LOXL4, lysyl oxidase-like 4; RGS12, regulator of G-protein signaling 12; TCTA, T-cell leukemia translocation-associated gene; TNF, tumor-necrosis factor.