Table 2.
Pretreatment | Posttreatment | 3 mo. follow-up | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Group | Mean | SD | Mean | SD | Pre to post effect size | Mean | SD | Pre to 3 mo. effect size | Test | |
CPSSa | CBT+DCS | 33.3 | 10.9 | 16.8 | 12.5 | 1.5 | 16.3 | 12.5 | 1.5 | Drug p<0.0001 |
CBT+P | 26.3 | 9.2 | 9.3 | 8.0 | 1.9 | 10.0 | 6.7 | 2.0 | Time p<0.0001 | |
Drug×time NS | ||||||||||
CDIa | CBT+DCS | 33.0 | 11.3 | 21.7 | 10.2 | 1.0 | 19.5 | 12.7 | 1.1 | Drug p<0.0001 |
CBT+P | 28.1 | 7.8 | 16.2 | 7.8 | 1.5 | 15.8 | 5.7 | 1.8 | Time p<0.0001 | |
Drug×time NS | ||||||||||
SCAREDa | CBT+DCS | 50.2 | 16.0 | 36.4 | 18.3 | 0.9 | 31.7 | 19.0 | 1.0 | Drug p<0.0001 |
CBT+P | 40.7 | 14.3 | 23.4 | 13.4 | 1.2 | 21.6 | 12.0 | 1.5 | Time p<0.0001 | |
Drug×time NS | ||||||||||
ODDb | CBT+DCS | 11.1 | 8.4 | 7.9 | 7.5 | 0.4 | 8.4 | 8.7 | 0.3 | Drug p<0.0001 |
CBT+P | 10.6 | 8.4 | 5.5 | 6.2 | 0.6 | 6.6 | 6.5 | 0.5 | Time p<0.0001 | |
Drug×time NS | ||||||||||
Inattentionb | CBT+DCS | 17.4 | 11.0 | 10.8 | 10.2 | 0.6 | 10.8 | 10.1 | 0.6 | Drug p<0.0001 |
CBT+P | 15.4 | 8.0 | 8.5 | 7.1 | 0.9 | 9.8 | 7.3 | 0.7 | Time p<0.0001 | |
Drug p<0.05 | ||||||||||
Hyperactivityb | CBT+DCS | 8.3 | 6.6 | 6.4 | 7.5 | 0.3 | 6.4 | 7.6 | 0.3 | Drug p<0.0001 |
CBT+P | 7.7 | 7.2 | 4.7 | 6.4 | 0.4 | 4.8 | 5.7 | 0.5 | Time p<0.0001 | |
Drug×time NS |
Either/or joint ratings from youth and parents.
Parent ratings.
CBT, cognitive behavioral therapy; DCS, D-cycloserine; CPSS, Child Posttraumatic Stress Disorder (PTSD) Symptom Scale; P, placebo; NS, not significant; CDI, Child Depression Inventory; SCARED, Screen for Child Anxiety Related Disorders; ODD, oppositional defiant disorder.