FIG. 6.

Results of real-time PCR revealed fenretinide specifically inducing the expression of ER stress-related genes in CML CD34⁺ cells. (A) Real-time PCR examine the expression level of genes related to UPR to oxidative stress, cholesterol metobolic process, and ER stress-induced apoptosis, which were functional enriched in microarray data, in CML CD34⁺ cells and mononuclear cells exposed to fenretinide for 48 h (n=6). (B) Endogenous mRNA levels of representative gene products induced by TCF11 and AP1 by real-time PCR in CML CD34⁺ cells exposed to fenretinide for 48 h (n=6). ER, endoplasmic reticulum; UPR, unfolded protein response; PCR, polymerase chain reaction.