Table 4.
Adjusted Odds Ratio (OR) for Side Effect Rating as Moderate or Severe
| Moderate or severe side effect rating | ||||
|---|---|---|---|---|
| Level | Type of side effect | ORa | 95% CI | Type 3 p value |
| One medication | 1 | |||
| Two medications | Decreased appetite | 1.01 | (0.70, 1.44) | 0.98 |
| Insomnia | 1.25 | (0.87, 1.81) | 0.23 | |
| Irritability | 1.29 | (0.87, 1.89) | 0.21 | |
| Headaches | 0.86 | (0.48, 1.55) | 0.62 | |
| Sleepiness or fatigue | 2.86 | (1.77, 4.62) | <0.001 | |
| Gastrointestinal upset | 1.53 | (0.84, 2.76) | 0.16 | |
| Increased appetite | 2.42 | (1.60, 3.67) | <0.001 | |
| Tics or tremors | 0.86 | (0.35, 2.12) | 0.75 | |
| Eye problems | 1.39 | (0.52, 3.70) | 0.51 | |
| Thinking about suicide | 4.7 | (1.20, 18.42) | 0.03 | |
| Intentional self-harm | 2.01 | (0.79, 5.11) | 0.14 | |
| Problems with blood tests | 3.99 | (0.73, 21.88) | 0.11 | |
| Three or more medications | Decreased appetite | 0.62 | (0.37, 1.03) | 0.07 |
| Insomnia | 0.73 | (0.42, 1.25) | 0.25 | |
| Irritability | 1.19 | (0.73, 1.94) | 0.5 | |
| Headaches | 1.07 | (0.54, 2.10) | 0.85 | |
| Sleepiness or fatigue | 3.01 | (1.74, 5.21) | <0.001 | |
| Gastrointestinal upset | 2.51 | (1.34, 4.69) | <0.001 | |
| Increased appetite | 4.28 | (2.70, 6.78) | <0.001 | |
| Tics or tremors | 4.48 | (2.20, 9.12) | <0.001 | |
| Eye problems | 1.07 | (0.29, 3.96) | 0.91 | |
| Thinking about suicide | 10.03 | (2.60, 8.76) | <0.001 | |
| Intentional self-harm | 4.66 | (1.89, 1.50) | <0.001 | |
| Problems with blood tests | 1.79 | (0.16, 19.99) | 0.64 | |
a
OR derived from the generalized multivariate binomial model with side effect intensity relative to using one medication. Adjusted for covariates of age, gender, race, region of residence, maximum medication duration, care access difficulties, health insurance type, and household income.