FIG. 4.

ROS mediate adipocyte differentiation from MSCs. Nox4, a NADPH oxidase isoform, is one of the sources of ROS in rat MSCs and is essential during differentiating MSCs to adipocytes. ROS is blocked on silencing Nox4, or addition of NAC antioxidant or PrxII ROS scavenger, which in turn does not activate CREB, thus blocking adipocyte differentiation. MSCs, mesenchymal stem cells. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars