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. 2014 Apr 20;20(12):1902–1916. doi: 10.1089/ars.2013.5300

FIG. 4.

FIG. 4.

ROS regulation of signaling pathways in stem cells. (A) In stem cells, a variety of proteins that respond to ROS can determine cellular outcomes, such as whether to enter the cell cycle or remain quiescent. Proteins, including transcription factors p53, PDRM16, FoxO, and NRF2 can, in turn, regulate levels of ROS. (B) A schematic of effects of ROS in stem cells. ATM, ataxia telangiectasia mutated

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