Figure 4.
Tumors alter LPS-induced indolamine 2,3-deoxygenase (IDO) mRNA expression in the brain. Mean ± SEM Ido mRNA in the (A) hippocampus, (B) hypothalamus, and (C) frontal cortex of rats with or without mammary carcinomas 4 or 24 h after i.p. injection with LPS or 24 h after i.p. injection with saline (n=7–12 rat/treatment). Ido was undetectable for the majority 72% of samples in the 24 h post-LPS groups (see Methods). *p ≤ 0.05 between tumor and no tumor values #p ≤ 0.05 between LPS and respective saline values