TABLE 5.
Chronic Hg Dose-Response Effects in Year 7 Among Boys and Girls by WT or Mut Allelic Status for COMT SNPs
| rs4680 |
rs4633 |
rs4818 |
rs6269 |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | WT |
Mut |
WT |
Mut |
WT |
Mut |
WT |
Mut |
||||||||
| Measure | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | rpart (p) | Beta (SE) | |
| Boys | ||||||||||||||||
| Attention/Concentration | ||||||||||||||||
| Stroop Test: Color | −7.20 (3.94) | −.23 (.18) | −13.79 (6.23) | −.48 (.04) | ||||||||||||
| WAIS–III – Spatial Span | −1.24 (.97) | −.21 (.21) | −5.05 (1.95) | −.52 (.02) | −1.27 (.99) | −.22 (.21) | −4.58 (1.84) | −.53 (.02) | ||||||||
| Visual–Spatial | ||||||||||||||||
| WAIS–III – Digit Symbol | −6.74 (5.58) | −.20 (.24) | −32.46 (11.28) | −.56 (.01) | −6.76 (5.74) | −.20 (.25) | −35.71 (10.87) | −.64 (.005) | −7.96 (8.45) | −.21 (.36) | −17.92 (6.80) | −.44 (.01) | ||||
| WAIS–III – Symbol Search | −2.89 (2.28) | −.21 (.21) | −16.49 (5.52) | −.58 (.008) | −2.92 (2.30) | −.22 (.21) | −16.19 (5.53) | −.59 (.01) | −5.35 (3.11) | −.35 (.10) | −8.48 (3.83) | −.38 (.04) | ||||
| Motor | ||||||||||||||||
| WRAVMA –Pegs – Dominant | −6.15 (2.50) | −.36 (.02) | 3.72 (4.84) | .23 (.46) | ||||||||||||
| Girls | ||||||||||||||||
| Attention/Concentration | ||||||||||||||||
| Stroop Test: Color | 8.61 (2.70) | .54 (.004) | 6.60 (3.70) | .36 (.09) | ||||||||||||
| Adult Trails A | −3.06 (2.57) | −.18 (.24) | 9.24 (6.21) | .41 (.16) | −3.08 (2.73) | −.17 (.27) | 10.62 (6.46) | .44 (.13) | ||||||||
| Learning & Memory | ||||||||||||||||
| RAVLT – Trial 8: A post 20′ | −.58 (.61) | −.15 (.35) | −2.29 (1.06) | −.55 (.05) | ||||||||||||
Note. Values in bold signify p ≤ 0.05 in the direction of impaired performance with increasing Hg exposure. Values in bold italics signify p ≤ .05 in direction of improved performance with increasing Hg exposure.