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. Author manuscript; available in PMC: 2015 Mar 4.
Published in final edited form as: Circulation. 2014 Jan 15;129(9):1009–1021. doi: 10.1161/CIRCULATIONAHA.113.003863

Figure 3.

Figure 3

Expression signature of lncRNAs, but not mRNAs or miRNAs, distinguishes failing human hearts of ischemic and non-ischemic origin. (A-C)Unsupervised hierarchical clustering of the expression profiles of human cardiac mRNAs (A), miRNAs (B) and lncRNAs (C) reveals that all three distinguish failing from non-failing LV samples. In addition, the lncRNA, but not the mRNA or miRNA, expression profiles discriminate ICM from NICM LV samples. (D-F)Principal component analyses of mRNA (D), miRNA (E) and lncRNA (F) expression profiles showed similar findings. The variance explained by the principal components chosen is shown on top of each plot. (G)Heat map and unsupervised hierarchical clustering of lncRNA expression profiles derived from the microarray data of an independent cohort of human cardiac samples (11 NF, 11 ICM and 15 NICM) showed that lncRNA expression signature correctly classified all but one sample in all three groups.