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. Author manuscript; available in PMC: 2015 Mar 4.
Published in final edited form as: Circulation. 2014 Jan 15;129(9):1009–1021. doi: 10.1161/CIRCULATIONAHA.113.003863

Figure 6.

Figure 6

Expression levels of many cardiac lncRNAs are positively correlated with neighboring coding genes. (A-C)Histograms of Pearson correlations between random gene pairs (A) mRNA:cis-mRNA (B) and lncRNA:cis-mRNA gene pairs (C) reveals a strong positive correlation between lncRNAs and cis-mRNAs (C), compared with either mRNA:cis-mRNA (B) or random gene pairs (A). (D)Read distributions of a HF-associated lncRNA, n340651 (blue boxes), and its neighboring coding gene RARA (brown boxes), in NF, ICM and NICM LV samples. (E,F)Scatter plots of n340651 and RARA expression levels in individual human LV samples determined by RNASeq (E) and qPCR (F); both analyses reveal strong correlations for this lncRNA:cis-mRNA gene pair.