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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Immunol. 2014 Mar 3;192(7):3156–3165. doi: 10.4049/jimmunol.1301726

Figure 5. The neonatal transcriptome is fundamentally different at baseline compared to the murine adult.

Figure 5

A. Heat map showing the gene expression patterns of naïve neonatal (N), young adult (A), and elderly (E) control mice. Gene expression patterns from young adult and elderly mice could not be differentiated genomically at baseline by an unsupervised analysis. There were 5,798 probe sets (representing 3987 genes) differentially expressed between neonatal and adult mice (including young adult and elderly) that were significant at p<0.001. The overall pattern of gene expression was significantly different as determined by leave-one-out cross-validation. B. Fold changes of selected immune related genes from neonatal control mice compared to adult control mice. Neonatal mice have increased suppression of genes involved in adaptive immunity including MHC II, and decreased expression of genes involving innate immunity and inflammation (p<0.001). C. Categories of functional pathways containing genes that are either up or down regulated in naïve neonatal control mice as compared to adult control mice from Ingenuity Pathway Analysis (IPA).